HIGH UPTAKE OF C-14-LABELED D-AMINO ACIDS BY VARIOUS TUMORS

Abstract

As an extension of the previous findings that radioactivity of 14C-labeled D-amino acids after injection is localized preferentially in the tumor and the pancreas of tumor-bearing animals as compared with the corresponding L-amino acids tested, the results of similar uptake experiments using other tumors are reported. The present studies show high radioactivity uptake by human colon cancer, thyroid cancer and leiomyosarcoma transplanted into nude mice, and by solid leukemia L1210 and solid sarcoma 180, but not by Morris hepatoma 7316A or 3''-methyl-4-(dimethylamino)azobenzene-induced rat hepatoma. 11C-labeled D-amino acids may be useful for the detection of some cancers.