Intracoronary Administration of Streptokinase in a Canine Model: Disturbances in Thromboxane A2-Prostacyclin Balance
- 28 February 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Investigative Radiology
- Vol. 21 (3), 206-209
- https://doi.org/10.1097/00004424-198603000-00003
Abstract
The potential impact of local intracoronary infusion of streptokinase (SK) on vascular prostaglandin synthetic pathways was studied in a canine model. Control animals (n = 10) underwent left coronary artery (LCA) infusion of 50,000 units SK for 90 minutes; experimental animals (n = 10) underwent LCA infusion of normal saline. Plasma samples for radioimmunoassay (RIA) of prostacyclin (PGI-2) and thromboxane (TXA-2) were obtained from the coronary sinus (CS) as follows: one sample preinfusion, six samples during infusion, and three samples postinfusion in each animal. Comparisons between control and experimental plasma levels of PGI-2 and TXA-2 were made for each sampling time. The PGI-2 levels remained at or below the lower limits of detectability by RIA (the most sensitive assay available) in both control and experimental animals. TXA-2 levels were higher in experimental than in control animals at all sampling times, with the most significant differences occurring in samples 3 (after 30 minutes of infusion, .001 < P < .01), 4 (after 45 minutes of infusion, .05 < P < .10), and 5 (after 60 minutes of infusion, .02 < P < .05). We suggest (1) it is unlikely that any of the beneficial effects of coronary streptokinase infusions are PGI-2-mediated, (2) that the TXA-2 increases in our model may represent a pathophysiologic-biochemical correlate of previously identified morphologic evidence of endothelial damage in animals infused with fibrinolytic agents, and (3) that our findings may indicate that fibrinolytic infusions produce competing effects: lysis of thrombi and endothelial injury with TXA-2 production. Investigation into a possible dose response relationship and possible adjunctive use of antiplatelet drugs, antithromboxane drugs, and calcium channel blockers is warranted.This publication has 14 references indexed in Scilit:
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