Analysis of Heparan Sulfate Oligosaccharides with Ion Pair-Reverse Phase Capillary High Performance Liquid Chromatography-Microelectrospray Ionization Time-of-Flight Mass Spectrometry

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Abstract
The exact sequence determination of glycosaminoglycans such as heparan sulfate is very challenging because samples for analysis are only available in very small quantities and structural complexity is high. The present paper presents some significant technical advances in sequencing of these oligosaccharides. By a combination of liquid chromatography and mass spectrometry the characterisations of large and complex oligosaccharides...