ACUTE TOXICITY STUDIES ON ETHANOL, PROPANOL, AND BUTANOL
- 1 November 1964
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 42 (6), 689-696
- https://doi.org/10.1139/y64-078
Abstract
Three series of 10 dogs each were used to study the effects of intravenously administered ethanol, propanol-1, and butanol-1. In normothermic dogs, with supported respiration and nitrous oxide anaesthesia (after induction), the mean lethal doses for ethanol, propanol-1, and butanol-1 were 4.90, 2.42, and 1.26 gAg respectively. At a constant infusin rate, the blood alcohol levels increased almost linearly with time. Relationships between ethanol, propanol-1, and butanol-1 blood levels and blood pressure, pulse, and electrocardiogram were established. Two minutes cardiac standstill occurred at the following blood levels: ehtanol, 1499 mg/100 ml; propanol-1, 713 mg/100 ml; butanol-1, 279 mg/100 ml.Keywords
This publication has 5 references indexed in Scilit:
- Effect of acute alcohol intoxication on steroid output of rat adrenals in vitroAmerican Journal of Physiology-Legacy Content, 1963
- Relative Intoxicating Effects on Rats of Ethyl, Propyl and Butyl AlcoholsActa Pharmacologica et Toxicologica, 1960
- UNSPECIFIC DRUG ACTION. THE EFFECTS OF A HOMOLOGOUS SERIES OF PRIMARY ALCOHOLSBritish Journal of Pharmacology and Chemotherapy, 1960
- The Effect of Alcohol on Myocardial and Respiratory Function. The Influence of Modified Respiratory Function on the Cardiac Toxicity of AlcoholQuarterly Journal of Studies on Alcohol, 1952