HYPERGRANULAR PROMYELOCYTIC LEUKEMIA (APL) - CYTOGENETIC AND ULTRASTRUCTURAL SPECIFICITY
- 1 January 1978
- journal article
- research article
- Vol. 52 (2), 272-280
Abstract
Cytogenetic and ultrastructural findings were important diagnostic indicators of APL in a patient whose bone marrow morphology appeared, by light microscopy, to be similar to that in acute myeloblastic leukemia (AML) with maturation. Peripheral blood smears and bone marrow specimens examined by light microscopy showed few cells with the numerous coarse, azurophilic granules typical to APL. Cytogenetic analyses with several banding techniques of cells from bone marrow and unstimulated peripheral blood revealed the 15; 17 translocation, which was observed only in APL. A reinterpretation of the reciprocal translocation, based on R banding, suggests that the breakpoints are distal to q24 in no. 15 and at or near the junction of q21 and q22 in no. 17. The patient also had disseminated intravascular coagulation. The characteristic morphology of granules seen in APL was observed in this case only when transmission electron microscopy was used, since the granules were quite small. Since treatment for AML differs from that for APL, identification of the 15; 17 translocation and ultrastructural evidence of granules represent valuable diagnostic aids for APL.This publication has 4 references indexed in Scilit:
- Further evidence for a non‐random chromosomal abnormality in acute promyelocytic leukemiaInternational Journal of Cancer, 1977
- Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative GroupBritish Journal of Haematology, 1976
- ACUTE NONLYMPHOCYTIC LEUKEMIA IN ADULTS - CORRELATIONS WITH Q-BANDED CHROMOSOMES1976
- CHROMOSOMAL BANDING-PATTERNS IN ACUTE NONLYMPHOCYTIC LEUKEMIA1976