Resistance-Transfer Factor in Enterobacteriaceae
- 4 August 1966
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 275 (5), 248-252
- https://doi.org/10.1056/nejm196608042750504
Abstract
IN recent years pathogenic enterobacteriaceae have become increasingly resistant to many antibiotics.§ 1 2 3 Japanese workers showed in 1959 that resistance to multiple antibiotics in many strains of shigella was infectious — that is, that it could be transmitted by conjugation from resistant shigellas to sensitive strains of Escherichia coli.1 Further investigation showed this to be due to the transfer of an extrachromosomal genetic element, the resistance-transfer factor. The factor which is reproduced in the progeny endows them with resistance to multiple antibiotics. Similarly, infectious resistance has been demonstrated in many strains of salmonella, Esch. coli and other gram-negative bacilli . . .Keywords
This publication has 3 references indexed in Scilit:
- Characterization of a Transfer Factor Associated with Drug Resistance in Salmonella typhimuriumNature, 1965
- INFECTIOUS DRUG RESISTANCEBritish Medical Bulletin, 1965
- Salmonellosis and ShigellosisAnnals of Internal Medicine, 1962