Chromatin fine structure of active and repressed genes
- 1 January 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 289 (5794), 198-203
- https://doi.org/10.1038/289198a0
Abstract
Micrococcal nuclease digestion was used to compare the structures of actively transcribing and inert chromatin of the genes coding for the major heat-shock protein of Drosophila melanogaster. The repressed hsp 70 genes were considerably more resistant to cleavage by micrococcal nuclease than their flanking regions and the bulk of chromatin. The active genes, previously shown to be more sensitive than the repressed genes, are also more susceptible to the nuclease than their 3''-flanking regions and bulk chromatin.This publication has 33 references indexed in Scilit:
- Nucleosome StructureAnnual Review of Biochemistry, 1980
- Nucleosome Structure III: The Structure and Transcriptional Activity of the Chromatin Containing the Ovalbumin and Globin Genes in Chick Oviduct NucleiPublished by Cold Spring Harbor Laboratory ,1978
- Summary: The Molecular Biology of the Eukaryotic Genome Is Coming of AgePublished by Cold Spring Harbor Laboratory ,1978
- The structure of histone-depleted metaphase chromosomesCell, 1977
- Selective degradation of integrated murine leukemia proviral DNA by deoxyribonucleasesCell, 1977
- Structure of ChromatinAnnual Review of Biochemistry, 1977
- The chromosome fiber: Evidence for an ordered superstructure of nucleosomesChromosoma, 1977
- Isolation, characterization, and structure of the folded interphase genome of Drosophila melanogasterCell, 1976
- Solenoidal model for superstructure in chromatin.Proceedings of the National Academy of Sciences, 1976
- CHROMOSOME STRUCTUREAnnual Review of Genetics, 1970