Alterations of myc , myb , and ras Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical Correlation

Abstract

Alterations of c-myc, c-rasHa, or c-myb oncogenes were found in more than one-third of human solid tumors. Amplification of c-myc occurred in advanced, widespread tumors or in aggressive primary tumors. Apparent allelic deletions of c-rasHa and c-myb can be correlated with progression and metastasis of carcinomas and sarcomas.