THE effects of atropine when given in therapeutic doses are dramatic. When it is given in doses that may cause poisoning, the results are sometimes extremely serious or even fatal. The exact incidence of such poisoning is not known. Deaths from this cause constituted an extremely small percentage of those from poisoning in Massachusetts from 1928 to 1937 — considerably less than 1 per cent.1 There are several reports of cases of poisoning and of recovery with doses of atropine varying from 0.4 to 100 mg.34567 In each of these cases the reaction followed a distinct pattern, the differences between . . .