Exchange of valine-oxygen during the biosynthesis of δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine
- 1 January 1991
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 21,p. 1531-1532
- https://doi.org/10.1039/c39910001531
Abstract
Incubation of [18O2]valine with purified ACV synthetase from Cephalosporium acremonium gave exclusive incorporation of a single 18O label into δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (ACV), consistent with the formation of a covalent valinoyl-ACV synthetase complex.This publication has 9 references indexed in Scilit:
- Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. Evidence for the presence of phosphopantothenate in ACV synthetase.The Journal of Antibiotics, 1991
- Biochemistry of Peptide AntibioticsPublished by Walter de Gruyter GmbH ,1990
- δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine Synthetase from Aspergillus nidulansPublished by Elsevier ,1989
- The fate of valine-oxygen during penicillin biosynthesisJournal of the Chemical Society, Chemical Communications, 1989
- The biosynthesis of penicillins and cephalosporinsNatural Product Reports, 1988
- δ -(L-α-Aminoadipyl)-L-cysteinyl-D-valine synthetase (ACV synthetase): a multifunctional enzyme with broad substrate specificity for the synthesis of penicillin and cephalosporin precursorsJournal of the American Chemical Society, 1987
- Gramicidin S synthetase. Temperature dependence and thermodynamic parameters of substrate amino acid activation reactionsBiochemistry, 1985
- Partial elimination of valine-oxygen during penicillin biosynthesisJournal of the Chemical Society, Chemical Communications, 1981
- Attempts to Map a Process Evolution of Peptide BiosynthesisScience, 1971