Wetting characteristics and blood clotting on surfaces of copoly(γ‐Benzyl‐L‐glutamate, γ‐hydroxyethyl‐L‐glutamine)

Abstract

The film surface of poly(γ‐benzyl‐L‐glutamate) (PBLG) was modified with 2‐aminoethanol to enhance its hydrophilicity. Controlling the reaction conditions of PBLG and 2‐aminoethanol, various types of copoly(γ‐benzyl‐L‐glutamate, γ‐hydroxyethyl‐L‐glutamine) film surfaces were obtained. Surface free energy (γ_sv), the dispersive component of γ_sv (γ ), the nondispersive component of γ_sv (γ ), and the interfacial free energy of polymer surface with water (γ_sw), which were obtained by using the contact angle measurement and calculation method proposed by Andrade et al., were changed remarkably by the aminolysis. The γ_sv value increased after 2 h of aminolysis from 48.2 (PBLG) to 65.3 dyn/cm and gradually increased to around 70 dyn/cm after 12 h reaction. (γ ) and (γ ) changed from 31.0 and 17.2 dyn/cm (PBLG) to 26.5 and 44.3 dyn/cm, respectively. These parameters of the material surfaces, modified over 12 h reaction, were found to be similar to those of the surfaces of canine aorta, vein, and human fibrin membrane. Blood clotting times on these polymer surfaces were comparatively longer than on siliconized glass surfaces.