Inhibition of xanthine oxidase by anthraquinones.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (10), 4314-4316
- https://doi.org/10.1248/cpb.35.4314
Abstract
Inhibitory activities of nine anthraquinone derivatives against xanthine oxidase (EC 1.2.3.2) were assayed in vitro. Anthragallol (1,2,3-trihydroxyanthraquinone, 8) was the most active inhibitor among them. The concentration of 8 in the assay mixture required to give 50% inhibition (IC50) was 1.2 .times. 10-5 M. The type of inhibition by 8 with respect to xanthine as a substrate was uncompetitive.This publication has 9 references indexed in Scilit:
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