Performed 4 experiments with male Sprague-Dawley rats (n = 103) in which the saccharin ingestion of alloxan-diabetic, alloxan-nondiabetic, and controls was measured in a 2-choice preference situation. Results indicate that under a wide variety of procedures alloxan-diabetic Ss reject saccharin, but alloxan-nondiabetic Ss do so only when they are exposed to saccharin immediately following the administration of alloxan. It is concluded that injection of alloxan can serve as the UCS for taste-aversion learning under a restricted set of conditions but that hyperglycemia induces a saccharin aversion independently of this associational mechanism. (PsycINFO Database Record (c) 2006 APA, all rights reserved)