Asymmetric Reduction of Aromatic Ketone in a Continuous Flow System
- 1 October 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 59 (10), 3329-3331
- https://doi.org/10.1246/bcsj.59.3329
Abstract
When THF–borane (1/1) and aromatic ketone were supplied continuously to the column containing polymer-supported (S)-(−)-2-amino-3-(p-hydroxyphenyl)-1,1-diphenyl-1-propanol, the chiral product, secondary benzylic alcohol, could be obtained successfully (>90% ee). Large quantities of highly optically pure alcohol could be produced by the continuous flow system by the use of only a small amount of polymeric auxiliary.Keywords
This publication has 2 references indexed in Scilit:
- Recent developments in the application of functionalized polymers in organic synthesisPolymer, 1983
- Asymmetric reduction by nadh model compounds bound to polystyrene beads. Influence of spacer on the optical yieldJournal of Polymer Science Part C: Polymer Letters, 1981