THOUGH poisoning due to bromides has been a known entity since 1927,1 this diagnostic possibility is not considered with sufficient promptness in the case of patients with obscure psychiatric and neurologic problems admitted to a general hospital. Moreover, the large number of cases of toxicity due to bromides prescribed by a physician indicates that the condition should again be brought strongly to the attention of the members of the medical profession. Perusal of the records of a large series of patients was productive of a number of facts of great interest. ANALYSIS OF CASES The cases forming the basis of this paper were observed at the Boston City Hospital during the years 1931 through 1948. The total number of patients discharged with a diagnosis of bromide intoxication over this period was 68; but the cases only of those with a characteristic history, physical examination and course were accepted, with