Recovery of New Viruses (Coryzavirus) from Cases of Common Cold in Human Adults

Abstract

Viruses were recovered in diploid cell cultures of human fetal lung or kidney from cases of common cold in human adults and children. These agents, which comprise at least 4 serologic groups, appear to be related etiologically to the common cold in man. Because of their association with coryzal disease and for purpose of designation the agents are called coryzavirus. Coryzavirus failed to propagate in HeLa or grivet renal cell cultures, did not produce pathology in common laboratory hosts, and appears to be unrelated to the known respiratory viruses of man. Similarities to and differences from the "spectrum" of "Salisbury" agents are discussed. The agent appears to be of very small particle size and is estimated to be about 17 to 18 mu in diameter. Other biological, biophysical and biochemical properties of coryzavirus are presented.