THE EFFECT OF 5-HYDROXYTRYPTAMINE ON THE COTTON PELLET LOCAL INFLAMMATORY RESPONSE IN THE RAT
Open Access
- 1 March 1967
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 125 (3), 501-510
- https://doi.org/10.1084/jem.125.3.501
Abstract
The cotton pellet technique was used to evaluate the effect of 5-HT [5-hydroxytryptamine] and certain related compounds on granuloma formation in the rat. 5-HT (10 mg/kg) significantly decreased granuloma formation, significantly increased adrenal weight, and significantly decreased thymus weight in normal rats, and significantly decreased granuloma formation and thymus weight in sham-operated rats. On the other hand, 5-HT [5-hydroxytryptamine] (10 mg/kg) significantly increased granuloma weight in adrenalectomized rats. Methysergide (1 mg/kg) blocked the inhibitory effect of 5-HT on granuloma formation as well as the changes in weight of adrenal and thymus glands. 5-HIAA [5-hydroxyindole acetic acid] (11 mg/kg) and 5-HTP [5-hydroxytryptophan] (13 mg/kg) failed to alter granuloma formation.This publication has 24 references indexed in Scilit:
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