Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia

Abstract

Serotonin 5-HT_1A and 5-HT₂ receptors were examined in the postmortem brains of controls and patients with chronic schizophrenia. In the prefrontal cortex from patients with schizophrenia, 5-HT_1A receptor binding was increased, while 5-HT₂ receptor binding was decreased, when compared to controls. The increased 5-HT_1A receptor binding or the decreased 5-HT₂ receptor binding was observed in both the patients who had been medicated with neuroleptics at time of death and those who had not, at least 2 months prior to death. Thus, abnormalities of 5-HT receptor subtypes seem to exist in the brains of patients with chronic schizophrenia. 5-HT related agents might be beneficial for the treatment of schizophrenia.