The subthalamic nucleus: A possible target for stereotaxic surgery in parkinson's disease
- 1 January 1993
- journal article
- review article
- Published by Wiley in Movement Disorders
- Vol. 8 (4), 421-429
- https://doi.org/10.1002/mds.870080402
Abstract
Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism. We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.Keywords
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