Systemic and Coronary Hemodynamic Effects of Trimethaphan Camphorsulfonate (Arfonad) in the Dog

Abstract

The acute systemic and coronary hemodynamic effects of Arfonad were determined in 10 intact anesthetized mongrel dogs. A sustained 35% reduction in systemic arterial mean blood pressure was the end point of drug administration. The hemodynamic effects were consistent with peripheral pooling of blood, reduced central venous pressure and decreased cardiac work and coronary blood flow. The coronary sinus oxygen content decreased and cardiac efficiency was reduced. The results were basically similar to those obtained with longer acting ganglion blocking drugs.