CIMETIDINE IN THE TREATMENT OF GASTRIC-ULCER INDUCED BY STEROIDAL AND NON-STEROIDAL ANTI-INFLAMMATORY AGENTS

Abstract

Patients with gastric ulcers induced by anti-inflammatory agents, were studied to ascertain the effectiveness of cimetidine (Tagamet) when compared with intensified doses of antacids in their treatment. Patients [70] with medication-induced benign gastric ulcers confirmed by endoscopy and biopsy were studied. The agents principally responsible were aspirin, prednisone, ibuprofen, indomethacin and sulindac in standard pharmacologic doses. The study was carefully controlled to exclude confusing parameters. Patients were divided into 2 groups. Group I (38 patients) received cimetidine plus an antacid (Maalox). Group II (32 patients) received placebo tablets plus the same dose of antacid as in Group I. All anti-inflammatory agents were discontinued and patients were instructed to avoid known gastric irritants. Treatment periods lasted 6 wk. Confirmation of healing was by endoscopic evaluation.