ANTITUBERCULOUS IMMUNITY IN MICE VACCINATED WITH KILLED TUBERCLE BACILLI
Open Access
- 1 February 1953
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 97 (2), 221-233
- https://doi.org/10.1084/jem.97.2.221
Abstract
The resistance of white mice to tuberculous infection could be increased by preliminary vaccination with small amounts of tubercle bacilli killed by contact with 2 per cent phenol. Vaccine prepared from a variant strain of human tubercle bacilli unable to multiply in vivo (H37Ra) proved as active as vaccines prepared from either virulent or attenuated strains.Keywords
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