Nephrotoxicity after ifosfamide.
Open Access
- 1 July 1990
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 65 (7), 732-738
- https://doi.org/10.1136/adc.65.7.732
Abstract
Eleven children and adolescents with previously normal renal function who received ifosfamide for the treatment of extrarenal solid tumours underwent detailed investigation of glomerular and renal tubular function to assess the incidence and extent of renal damage. None had received cisplatin. Glomerular filtration rate (measured by plasma clearance of 51Cr labelled edetic acid) was reduced in six children. All 11 patients had evidence of proximal, and six of distal, tubular damage. Proximal tubular toxicity was indicated by phosphaturia and hypophosphataemia (n = 4), glycosuria (n = 5), increased urine beta 2 microglobulin excretion (n = 11), and generalised aminoaciduria (n = 10); distal tubular damage caused a reduction of the osmolality of the urine in an early morning sample. Two children developed clinical hypophosphataemic rickets, and one of these also had severe nephrogenic diabetes insipidus. Glomerular and tubular nephrotoxicity are common and potentially serious complications of ifosfamide treatment in children.Keywords
This publication has 37 references indexed in Scilit:
- IFOSFAMIDE-INDUCED FANCONI SYNDROMEThe Lancet, 1989
- Hypophosphataemic rickets after ifosfamide treatment in children.BMJ, 1989
- Fanconi syndrome after ifosfamideCancer Chemotherapy and Pharmacology, 1989
- Nephrotoxicity associated with ifosfamideEuropean Journal of Pediatrics, 1988
- Acyclovir-induced renal failureAmerican Journal Of Medicine, 1988
- A phase II study of ifosfamide in the treatment of recurrent sarcomas in young peopleCancer Chemotherapy and Pharmacology, 1986
- Present Status of Serum Tumor Markers in Diagnosis, Prognosis, and Evaluation of TherapyCancer Investigation, 1986
- Sodium-2-mercaptoethanesulfonate (MESNA) and Ifosfamide NephrotoxicityEuropean Journal of Cancer and Clinical Oncology, 1984
- Failure of 2-mercaptoethane sulphonate sodium (mesna) to protect against ifosfamide nephrotoxicityEuropean Journal of Cancer and Clinical Oncology, 1984
- Case of tumour rickets.Archives of Disease in Childhood, 1978