STUDIES ON CORTICOSTERONE C-20 REDUCTION IN THE MOUSE
- 1 December 1962
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 40 (12), 1797-1810
- https://doi.org/10.1139/o62-197
Abstract
The intravenous injection of corticosterone in the mouse was followed by liver assays for corticosterone and 20α- and 20β-dihydrocorticosterone. The 20α-epimer proved to be the more abundant product. Corticosterone 20α-reductase activity of mouse liver was shown to be associated with the dialyzed soluble fraction of the cell which served as an enzyme preparation for a study of certain properties of corticosterone 20α-reductase and the kinetics of the forward and reverse reactions.Keywords
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