HLA-B27-Transfected (SalmonellaPermissive) and HLA-A2-Transfected (SalmonellaNonpermissive) Human Monocytic U937 Cells Differ in Their Production of Cytokines

Abstract

The cytokine secretion of theSalmonella-permissive, HLA-B27-positive U937 cells was examined, as it was previously shown that these cells killSalmonellaless efficiently than controls.Salmonella-permissive U937 cells showed upregulated production of interleukin 10 and to a lesser extent tumor necrosis factor alpha. HLA-B27-associated modulation of cytokine responses may have importance in the pathogenesis of reactive arthritis.