Development of a model for the induction of estrogen-related prostatic hyperplasia in the dog and its response to the aromatase inhibitor 4-hydroxy-4-androstene-3,17-dione: Preliminary results
- 1 January 1986
- journal article
- research article
- Published by Wiley in The Prostate
- Vol. 8 (2), 181-194
- https://doi.org/10.1002/pros.2990080208
Abstract
Although the presence of the testes is an absolutely necessary prerequisite for benign prostatic hyperplasia (BPH) to occur, the role of androgens in the cause of BPH is still controversial. There are increasing signs for a decisive role of estrogens in that connection. We treated castrated beagle dogs of known age with androstenedione (an androgen that can be aromatized) and with the aromatase inhibitor 4‐hydroxyandrostendione. Six or 9 months of treatment with androstenedione resulted in a BPH characterized by typical androgenic effects—ie, hyperplasia and hypertrophy of the epithelium—and by typical estrogenic effects—, stimulation of the stroma, especially of the smooth muscles, and cystic enlargement of the tubules. These estrogen‐related effects could be clearly antagonized by the simultaneous treatment with the aromatase inhibitor 4‐hydroxyandrostenedione. The hyperplastic effects on the epithelium were also partly antagonized by the aromatase inhibitor. Our preliminary results further strengthen the effectiveness of aromatase inhibitors as an alternative treatment of human BPH, which is thought to be predominantly a stromal disease.Keywords
This publication has 25 references indexed in Scilit:
- Surgical Pathology of Benign Prostatic HyperplasiaPublished by Springer Nature ,1983
- Effects of Castration, Estrogen, and Androgen AdministrationPublished by Springer Nature ,1983
- Cellular Growth and Hormone ReceptorsPublished by Springer Nature ,1983
- Endocrine and Cellular Inductive Factors in the Development of Human Benign Prostatic HypertrophyPublished by Springer Nature ,1983
- Possible Causative FactorsPublished by Springer Nature ,1983
- Histopathology of prostatic tumoursPublished by Springer Nature ,1983
- The development and morphology of the prostatePublished by Springer Nature ,1983
- Concentration of Dihydrotestosterone and 3α-Androstanediol in Naturally Occurring and Androgen- Induced Prostatic Hyperplasia in the DogJCI Insight, 1979
- Dihydrotestosterone in prostatic hypertrophyJCI Insight, 1970
- Dihydrotestosterone in prostatic hypertrophyJCI Insight, 1970