Evidence for a chromosomal site specifying amikacin resistance in multiresistant Serratia marcescens
Open Access
- 1 April 1982
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 21 (4), 587-591
- https://doi.org/10.1128/aac.21.4.587
Abstract
We studied 21 strains of amikacin-resistant Serratia marcescens from three different U.S. cities, Twenty of the 21 strains contained conjugative R plasmids mediating gentamicin and tobramycin resistance. Amikacin-resistant S. marcescens from two cities predominated in protracted outbreaks. Conversely, the amikacin-resistant Charleston strain (serotype 02/03:nonmotile) was isolated from only four patients during an outbreak of gentamicin- and tobramycin resistant, amikacin-susceptible S. marcescens (serotype O19:O17). Five different representative amikacin-resistant S. marcescens, each containing a single conjugative plasmid, elaborated a nontransferable aminoglycoside (6')-N-acetyltransferase [AAC(6')] with similar substrate profiles in addition to other transferable aminoglycoside-modifying enzymes. One amikacin-resistant S. marcescens cured of its plasmid and another naturally occurring plasmid-free amikacin-resistant S. marcescens elaborated only AAC(6')-1. These data support the concept of a chromosomal locus in S. marcescens for AAC(6')-1 which commonly coexists with plasmid-mediated genes for aminoglycoside-modifying enzymes.This publication has 30 references indexed in Scilit:
- Characteristics of Serratia marcescens Containing a Plasmid Coding for Gentamicin Resistance in Nosocomial InfectionsThe Journal of Infectious Diseases, 1981
- Gene Transfer in Acinetobacter calcoaceticus: Fertility Variants of the Sex Factor pAV1Microbiology, 1980
- Characteristics of gentamicin resistance in nosocomial infectionsThe American Journal of the Medical Sciences, 1980
- Drug-Inactivating Enzymes of Bacteria Grown in Subminimal Inhibitory Concentrations of AntibioticsClinical Infectious Diseases, 1979
- Plasmid-Determined Resistance to Antimicrobial AgentsAnnual Review of Microbiology, 1978
- Aminoglycoside resistance among Enterobacteriaceae and Acinetobacter speciesJournal of Antimicrobial Chemotherapy, 1978
- Amikacin therapy. Use against infections caused by gentamicin- and tobramycin-resistant organismsPublished by American Medical Association (AMA) ,1977
- GENTAMICIN-RESISTANT KLEBSIELLA AEROGENES IN A UROLOGICAL WARDThe Lancet, 1977
- Discovery, Chemistry, and Activity of AmikacinThe Journal of Infectious Diseases, 1976
- Mechanisms of Antibiotic Resistance in BacteriaAnnual Review of Biochemistry, 1973