STEREOSELECTIVE SYNTHESIS OF 1-O-ACYL-d-GLUCOPYRANOSE FROM 1-HYDROXY SUGAR AND ACYL FLUORIDES BY THE PROMOTION OF CESIUM FLUORIDE

Abstract

In the presence of cesium fluoride, the reaction of 2,3,4,6-tetra-O-benzyl-D-glucopyranose with acyl fluorides affords the corresponding glucosyl esters in good yields under essentially neutral condition. The α⁄β ratio of produced glucosyl esters is greatly affected by reaction conditions and predominant formations of each anomer is achieved by procedures described herein.