Biosynthesis of 2-trans,6-trans- and 2-cis,6-trans-farnesols by soluble enzymes from tissue cultures of Andrographis paniculata

Abstract

A cell-free system from Andrographis paniculata tissue cultures incorporates ³H from (3RS)-[2-¹⁴C, 5-³H₂]mevalonate into trans,trans-farnesol without loss and into the cis,trans-isomer with loss of one sixth of the label; this strongly supports trans→cisisomerisation via aldehydes.