Desoxyribosenucleic Acid as Index of Mammary Gland Growth of Mice.

Abstract

. Total DNA of the mouse mammary gland is an index of mammary gland development while concentration ([mu]g DNA/mg dry, fat-free tissue) seems to be an index of growth rate. Feeding 1.23 mg diethylstilbestrol/kg mouse food caused most rapid mouse mammary duct development between the second and third weeks. Rate of mammary gland growth is not constant. At the end of a 10-day period, mice injected with lower doses of lobule-alveolar developing substances seemed to be developing at a faster rate, whereas those receiving a higher dose had a greater amount of absolute growth, although the rate of development had passed the peak.