Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology
- 1 August 2000
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 6 (8), 849-851
- https://doi.org/10.1038/78592
Abstract
Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.Keywords
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