Small but versatile: the extraordinary functional and structural diversity of the β-grasp fold
Open Access
- 2 July 2007
- journal article
- Published by Springer Nature in Biology Direct
- Vol. 2 (1), 18
- https://doi.org/10.1186/1745-6150-2-18
Abstract
The β-grasp fold (β-GF), prototyped by ubiquitin (UB), has been recruited for a strikingly diverse range of biochemical functions. These functions include providing a scaffold for different enzymatic active sites (e.g. NUDIX phosphohydrolases) and iron-sulfur clusters, RNA-soluble-ligand and co-factor-binding, sulfur transfer, adaptor functions in signaling, assembly of macromolecular complexes and post-translational protein modification. To understand the basis for the functional versatility of this small fold we undertook a comprehensive sequence-structure analysis of the fold and developed a natural classification for its members.Keywords
This publication has 133 references indexed in Scilit:
- Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinityNature, 2007
- Comparative genomics and structural biology of the molecular innovations of eukaryotesCurrent Opinion in Structural Biology, 2006
- Structure of the Escherichia coli ThiS−ThiF Complex, a Key Component of the Sulfur Transfer System in Thiamin Biosynthesis,Biochemistry, 2005
- Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1The EMBO Journal, 2005
- T-coffee: a novel method for fast and accurate multiple sequence alignment 1 1Edited by J. ThorntonJournal of Molecular Biology, 2000
- The Protein Data BankNucleic Acids Research, 2000
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997
- SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modelingElectrophoresis, 1997
- The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogueNature, 1995
- Structure of ubiquitin refined at 1.8 Å resolutionJournal of Molecular Biology, 1987