Effects of Acidosis on the Metabolism of Fructose

Abstract

Intraven. fructose tolerance tests on dogs in normal (fasting) states and in states of severe acidosis induced by intraven. perfusions of ammonium chloride soln. indicated that fructose disappeared at the same rate from the blood of non-acidotic and acidotic animals. Results of studies on the metabolism of fructose in blood in vitro indicate that fructokinase is probably absent from blood, and that acidosis inhibits the utilization of fructose by blood cells.