Blood copper as an indicator of copper status with a note on serum proteins and leucocyte counts in copper-deficient rats
- 1 February 1968
- journal article
- research article
- Published by Cambridge University Press (CUP) in British Journal of Nutrition
- Vol. 22 (1), 1-7
- https://doi.org/10.1079/bjn19680003
Abstract
1. Albumin, α1-, α2-, β- and γ-globulin fractions were demonstrated in serum from control and copper-depleted rats, but no quantitative difference was found in the distribution of the proteins between the two groups of animals. Both the total number of leucocytes and the number of polymorphonuclear leucocytes increased during copper depletion.2. Plasma copper content was found to be superior to whole blood copper content as an index of the copper status of rats at intermediate stages of depletion. The copper content of erythrocytes was found to be unaffected even in the severely depleted animals; this explains, in part, the poor response of whole blood copper content to intermediate stages of depletion.3. A single dose of orally administered copper was reflected in the plasma copper content of depleted rats about 12 h after dosing. No similar rise was observed in control animals, and the extent of the response was not increased by increasing the dose of copper.4. It is suggested that plasma copper response to a single oral dose of copper sulphate may provide a useful method for the detection of subnormal copper status in individual farm animals without the necessity of determining breed norms.Keywords
This publication has 10 references indexed in Scilit:
- Starch-gel electrophoresis of rat-serum proteinsBiochimica et Biophysica Acta, 1961
- Clinical Biochemistry of Farm AnimalsJournal of Comparative Pathology and Therapeutics, 1960
- Studies on Copper Metabolism. XXV. Relationship Between Serum and Liver Copper.Experimental Biology and Medicine, 1958
- Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adultsBiochemical Journal, 1955
- Studies on the Function and Metabolism of CopperJournal of Nutrition, 1953
- STUDIES ON COPPER METABOLISM. IX. THE TRANSPORTATION OF COPPER IN BLOOD 1JCI Insight, 1953
- Electrophoresis of Rat Sera1Journal of the American Chemical Society, 1944
- THE α-GLOBULIN FRACTION OF THE SERUM OF NORMAL AND HYPOPHYSECTOMIZED RATSPublished by Elsevier ,1944