DEMONSTRATION OF AGGLUTININS FIVE HOURS AFTER INTRAPERITONEAL INJECTION OF PNEUMOCOCCUS TYPE I IN GUINEA PIGS

Abstract

The inoculation of guinea pigs with pneumococci Type I intraperitoneally resulted in the development of homologous agglutinating antibodies, which were detected in the sera as early as five hours after inoculation. The early appearance of active immunity, and the attainment of a sufficient titer, would appear to govern survival to a fatal homologous re-infecting dose of the organism.