THE CONVERSION OF PROGESTERONE TO 16α-HYDROXY-PREGN-4-ENE-3,20-DIONE AND ANDROST-4-ENE-3,17-DIONE BY HUMAN PLACENTA IN VITRO
- 1 August 1963
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 43 (4), 510-520
- https://doi.org/10.1530/acta.0.0430510
Abstract
Using the soluble supernatant fraction of a homogenate of normal human placenta and employing reduced triphosphopyridine as cofactor, the conversion of progesterone to 16α-hydroxyprogesterone and androstenedione was demonstrated. Tests were made of the radiochemical purity of the products. The possible role of 16α-hydroxylated steroids for the biosynthesis of oestriol in pregnancy is discussed.Keywords
This publication has 17 references indexed in Scilit:
- Metabolism of C-16-oxygenated Steroids by Human Placenta: the Formation of EstriolJournal of Biological Chemistry, 1959
- Neue 16α‐Hydroxysteroide aus menschlichem Urin und aus Schweine‐Nebennieren. Isolierung, Konstitution, Synthesen. über Steroide, 156. MitteilungHelvetica Chimica Acta, 1959
- Δ4-3-KETOPREGNENE-20α-OL AND Δ4-3-KETOPREGNENE-20β-OL, TWO NATURALLY OCCURRING METABOLITES OF PROGESTERONE. ISOLATION, IDENTIFICATION, BIOLOGIC ACTIVITY AND CONCENTRATION IN HUMAN TISSUES*Journal of Clinical Endocrinology & Metabolism, 1958
- A chemical method for the determination of oestriol, oestrone and oestradiol in human urineBiochemical Journal, 1955
- PAPER PARTITION CHROMATOGRAPHY OF C19- AND C21-KETOSTEROIDSJournal of Biological Chemistry, 1953
- STUDIES IN STEROID METABOLISM .18. ISOLATION OF 3 NEW STEROID TRIOLS FROM HUMAN URINE1953
- UPTAKE OF RADIOACTIVE ALANINE IN VITRO INTO THE PROTEINS OF RAT LIVER FRACTIONSJournal of Biological Chemistry, 1952
- Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissuesBiochemical Journal, 1952
- STEROID EXCRETION IN A CASE OF ADRENOCORTICAL CARCINOMA .4. DELTA-5-PREGNENETRIOL-3-BETA,16-ALPHA,20-ALPHA1950
- A SIMPLE METHOD FOR ANALYZING COMPLICATED ABSORPTION CURVES, OF USE IN THE COLORIMETRIC DETERMINATION OF URINARY STEROIDSJournal of Clinical Endocrinology & Metabolism, 1950