Gli and hedgehog in cancer: tumours, embryos and stem cells
Top Cited Papers
- 1 May 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 2 (5), 361-372
- https://doi.org/10.1038/nrc796
Abstract
Do tumours arise from stem cells, or are they derived from more differentiated cells that, for some reason, begin to recapitulate developmental programmes? Inappropriate activation of the Sonic hedgehog-Gli signalling pathway occurs in several types of tumour, including those of the brain and the skin. Studies in these and other systems suggest that inappropriate function of the Gli transcription factors in stem or precursor cells might lead to the onset of a tumorigenic programme and that these factors are prime targets for anticancer therapies.Keywords
This publication has 123 references indexed in Scilit:
- Identification of Sonic Hedgehog-Responsive Genes Using cDNA MicroarrayBiochemical and Biophysical Research Communications, 2001
- Neuronal specification in the spinal cord: inductive signals and transcriptional codesNature Reviews Genetics, 2000
- The Hallmarks of CancerCell, 2000
- Sonic Hedgehog Opposes Epithelial Cell Cycle ArrestThe Journal of cell biology, 1999
- Reversible Activation of c-Myc in SkinMolecular Cell, 1999
- Sonic hedgehog signaling is essential for hair developmentCurrent Biology, 1998
- Gli/Zic factors pattern the neural plate by defining domains of cell differentiationNature, 1998
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNature Medicine, 1997
- Mutations in the human Sonic Hedgehog gene cause holoprosencephalyNature Genetics, 1996
- Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitroNeuron, 1991