On the optimal dosage of Pro-Leu-Gly-NH2 (MIF) in neuropharmacological tests and clinical use
- 1 June 1977
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 298 (2), 79-81
- https://doi.org/10.1007/bf00508614
Abstract
Summary Pro-Leu-Gly-NH2 (MIF) inhibits the tremor induced by oxotremorine. Objective measurement of this tremor permits the drawing of a dose-effect curve. The inhibitory effect of the peptide increases linearly with increasing doses until an optimum is reached (between 30 and 40 mg/kg i.p.). At still higher doses the peptide is inactive. The same phenomenon is observed with analogues of MIF. This finding may have important bearings on the interpretation of clinical and experimental data obtained with MIF.Keywords
This publication has 17 references indexed in Scilit:
- Neuropharmacology of hypothalamic releasing factorsBiochemical Pharmacology, 1976
- α-MSH and MIF-I effects on catecholamine levels and synthesis in various rat brain areasPharmacology Biochemistry and Behavior, 1975
- Intensification of central catecholaminergic and serotonergic processes by the hypothalamic factors MIF and TRF and by angiotensin IIPharmacology Biochemistry and Behavior, 1975
- Studies on the inhibition of oxotremorine induced tremor by a melanocyte‐stimulating hormone release‐inhibiting factor, thyrotropin releasing hormone and related peptidesFEBS Letters, 1974
- Oxotremorine antagonism by prolyl-leucyl-glycine-amide administered by different routes and with several anticholinergicsPharmacology Biochemistry and Behavior, 1974
- Effect of Melanocyte-Stimulating Hormone-Release Inhibiting Factor (MIF) in Parkinson’s SyndromEuropean Neurology, 1974
- Dopamine Synthesis: Stimulation by a Hypothalamic FactorScience, 1973
- Deserpidine Antagonism by a Tripeptide, L-Prolyl-L-LeucylglycinamideNeuroendocrinology, 1973
- DOPA Potentiation by a hypothalamic factor, MSH release-inhibiting hormone (MIF)Life Sciences, 1971
- The Up-and-Down Method for Small SamplesJournal of the American Statistical Association, 1965