Platelet-latelet-

Abstract

Thrombotic thrombocytopenic purpura was seen in 2 patients. Aspirin, dipyridamole and sulfinpyrazone were administered to patient 1 after splenectomy, administration of high dose prednisone and methylprednisolone failed to induce remission. The platelet count rose, but the patient had a relapse when the dipyridamole dose was tapered. This condition responded to an increase of the drug, and the patient obtained a long-lasting remission. A splenectomy was not performed on patient 2, and all 3 platelet-inhibiting drugs, with prednisone, were given. This resulted in a prompt remission that was sustained for 29 wk. Morphologic changes in the peripheral blood smear remained for several weeks after other features of the disease resolved. Thus, in both cases, platelet-inhibiting drugs appeared to induce remission.