Modulation of Expression of HLA Components at the Cell Surface Induced by Anti‐β2m Reagents
- 1 January 1981
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 17 (1), 28-36
- https://doi.org/10.1111/j.1399-0039.1981.tb00663.x
Abstract
Antibodies against lymphocyte surface components are able to rearrange profoundly the topography of the cell membrane with a differential modulation of surface antigens. Of particular interest is the effect of anti-β2m reagents, which are able to suppress completely the reactivity of epitopes carried by the two chains of the ABC dimers, while the expressivity of other antigens, such as DR, is significantly increased. These results have been obtained with immunoradiobinding under a variety of conditions, thus confirming the validity of the “bb” (β2m blanketing) test.This publication has 14 references indexed in Scilit:
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