Studies of Sulfobromophthalein Sodium (BSP) Metabolism in Man. II. The Effect of Artificially Induced Fever, Norethandrolone (Nilevar), and Iopanoic Acid (Telapaque)*

Abstract

Measurements of fractional clearance, 60-minute serum retention, relative storage capacity, conjugation, and maximum biliary excretion of sulfobromophthalein sodium in healthy volunteers were not influenced by a brief period of artificially-induced fever. Ingestion of norethandrolone (Nilevar) and of iopanoic acid (Telapaque) resulted in apparent defects of both hepatic uptake and biliary excretion of BSP. Increased reflux of conjugated BSP into the serum was noted during the course of continuous infusion of dye after administration of each drug. Because contrast medium may interfere with BSP transport, it seems preferable that gall bladder dye not be administered prior to determination of BSP retention as a clinical test of hepatic function.