Estrogen-induced synthesis of a specific uterine protein.

Abstract

The effects of estrogen on the incorporation of labeled amino acids into soluble uterine proteins was studied by starch-gel electrophoresis. Early induction of the synthesis of a single protein occurred within 30 min. after estrogen treatment and prior to the over-all stimulation of protein synthesis. The synthesis of this estrogen-induced protein was still demonstrable but at lowered levels in the presence of actinomycin D, suggesting that either its synthesis is under translational control or that RNA synthesis in the specific gene locus for this protein is not effectively suppressed by actinomycin D.