A circulating depressant effect following canine haemorrhagic shock
- 1 May 1973
- journal article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 60 (5), 392-394
- https://doi.org/10.1002/bjs.1800600521
Abstract
Following periods of 1 or 3 1/2 hours of haemorrhagic shock in 12 anaesthetized ventilated greyhounds, ultrafiltrates of plasma taken 4 hours after retransfusion exibited significantly increased depressant activity on guinea‐pig atrium in vitro. This effect was significantly greater following prolonged hypotension and could not be accounted for by changes in electrolyte composition. It is suggested that this effect may be related to defective myocardial function following haemorrhagic shock.Keywords
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