Tie receptors: new modulators of angiogenic and lymphangiogenic responses
- 1 April 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 2 (4), 257-267
- https://doi.org/10.1038/35067005
Abstract
Angiogenesis is required for normal embryonic vascular development and aberrant angiogenesis contributes to several diseases, including cancer, diabetes and tissue ischaemia. What are the molecular mechanisms that regulate this important process? The Tie family of receptors and their ligands, the angiopoietins, are beginning to provide insight into how vessels make decisions such as whether to grow or regress — processes that are important not only during development but throughout an organism's life.Keywords
This publication has 100 references indexed in Scilit:
- Structure of the Tie2 RTK DomainStructure, 2000
- Characterization and Expression of a Novel Alternatively Spliced Human Angiopoietin-2Published by Elsevier ,2000
- Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin PathwayJournal of Biological Chemistry, 2000
- Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the Angiopoietin receptor Tie-2Oncogene, 1999
- Characterization of a Novel Form of Angiopoietin-2 (Ang-2B) and Expression of VEGF and Angiopoietin-2 during Chicken Testicular Development and RegressionBiochemical and Biophysical Research Communications, 1999
- Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation responseOncogene, 1999
- The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-ROncogene, 1998
- Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endotheliumNature, 1995
- Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceNature, 1995
- Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem CellsBiochemical and Biophysical Research Communications, 1993