Genomes of diploblastic organisms contain homeoboxes: sequence ofeveC, aneven-skippedhomologue from the cnidarianAcropora formosa
- 22 May 1992
- journal article
- Published by The Royal Society in Proceedings Of The Royal Society B-Biological Sciences
- Vol. 248 (1322), 159-161
- https://doi.org/10.1098/rspb.1992.0057
Abstract
We report the nucleotide sequence of eveC, a cnidarian eve-class homeobox; this is the first homeobox to be identified in any diploblastic organism, and is only the second eve-class in an invertebrate. Similarity between the predicted amino acid sequence of the eveC homeodomain and its insect and vertebrate equivalents was approximately 75-80% but, in the case of eveC, a role in segmentation can be ruled out. Our findings thus support the 'co-option' hypothesis: homeoboxes were an early feature of metazoan genomes, corresponding to the DNA-binding domains of more general transcription factors.Keywords
This publication has 8 references indexed in Scilit:
- A Cluster of Antennapedia -Class Homeobox Genes in a Nonsegmented AnimalScience, 1991
- EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5′ end of HOX4 locus on chromosome 2Genomics, 1991
- Similarities between the homeodomain and the hin recombinase DNA-binding domainCell, 1991
- Evidence for a new family of evolutionarily conserved homeobox genesNucleic Acids Research, 1990
- Expression of engrailed proteins in arthropods, annelids, and chordatesCell, 1989
- Control of neuronal fate by the Drosophila segmentation gene even-skippedNature, 1988
- Molecular Phylogeny of the Animal KingdomScience, 1988
- Borders of parasegments in Drosophila embryos are delimited by the fushi tarazu and even-skipped genesNature, 1987