A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase
- 1 July 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 298 (5870), 136-140
- https://doi.org/10.1038/298136a0
Abstract
A covalent adduct of an aminoacyl tRNA synthetase and uracil nucleoside has been isolated. The enzyme adduct is catalytically inactive; one nucleoside is bound per catalytic site. The release of uridine restores enzyme activity. The nucleoside attaches to a protein segment required for tRNA interaction. The findings add support to concepts of a covalent component for some protein–nucleic acid complexes.This publication has 44 references indexed in Scilit:
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