Off-targeting oft-targeted CD20 in cHL
- 3 May 2012
- journal article
- editorial
- Published by American Society of Hematology in Blood
- Vol. 119 (18), 4095-4096
- https://doi.org/10.1182/blood-2012-03-413146
Abstract
We now think of classical Hodgkin lymphoma (cHL) as derived from "crippled" germinal center B cells that have frequently acquired rearranged and somatically mutated Ig genes.1,2 Despite their B-cell origin, the malignant Hodgkin and Reed-Sternberg (HRS) cells have lost most of the superficial trappings of B cells and therefore have been hidden from investigators' lenses for decades, prompting an arduous but persistent race to uncover the mystery of the HRS cell.Keywords
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