VARIABLE EFFECTS OF CORTICOSTEROID TREATMENT ON SERUM ENZYME-ACTIVITIES IN DUCHENNES MUSCULAR-DYSTROPHY

Abstract

Corticosteroid administration on alternate days to 5 boys with Duchenne''s muscular dystrophy (DMD) lowered the high serum creatine kinase and lactate dehydrogenase activities in 3, caused no change in 1, and increased these activities in 1. This therapy probably can partially normalize a major biochemical abnormality of this disease in some but not all patients with DMD.