DEPLETION OF MUSCLE SUGAR BY ADRENALIN. II

Abstract

The fall in muscle sugar below the resting level is observed during the recovery period following a subcut. or continuous in-traven. dose of adrenalin. The effective subcut. and continuous intraven. muscle sugar lowering doses of adrenalin are the same. The minimum muscle sugar lowering dose of adrenalin is greater than the minimum hyperglycemic dose. A physiological rate of injection over a long period of time reduces the muscle sugar below normal. When the muscle sugar was observed to be low following the action of adrenalin, the muscle glycogen was also low, but normal or high muscle sugar values were found with low muscle glycogen values. Under conditions in which blood sugar, muscle sugar, and muscle glycogen were affected by adrenalin, the polysaccharide sugar of the muscle was unaffected.