THE INFLUENCE OF ADRENERGIC BLOCKING AGENTS ON METABOLIC EVENTS IN HEMORRHAGIC SHOCK IN THE DOG

Abstract

Dibenamine hydrochloride given intravenously 30 minutes after the onset of hemorrhage in anesthetized dogs, in which hemorrhagic hypotension (43-45 mm Hg for 90 minutes) of the Wiggers'' type was produced, resulted in increased survival rate as compared to that of untreated controls. The mean increase in plasma amino N and the percentage decrease in total arterial O2 transport were significantly less in the Dibenamine-treated group. Animals treated with Dibenamine or Dibenzyline hydrochloride 85 minutes after hemorrhage as compared to untreated controls, showed no significant differences in survival rate, plasma amino N, lactate, pyruvate, lactate/pyruvate ratio, bicarbonate content, or blood pH. Arterial O2 transport, however, was significantly higher after than before treatment and also in the postinfusion period was higher in the 2 treated groups than in the untreated group. In these 2 late-treated groups, however, the plasma amino N increase was significantly greater in fatalities than in survivors during both hypotensive and postinfusion periods. In the untreated group, differences between survivors and fatalities appeared only after reinfusion of withdrawn blood.